Flavonoids protect mice from two types of lethal shock induced by endotoxin

K. Takahashi, A. Morikawa, Y. Kato, T. Sugiyama, N. Koide, M. M. Mu, T. Yoshida, T. Yokochi

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The protective effect of flavonoids on two types of lethal endotoxic shock was studied. A lethal endotoxic shock was induced by administration of lipopolysaccharide (LPS) into D-galactosamine (D-GalN)-sensitized mice and another one was done by administration of a high dose of LPS into normal mice. Pretreatment with a series of flavonoids protected mice from two types of endotoxin lethality. Flavonoid pretreatment reduced the serum tumor necrosis factor-α (TNF-α) level in mice injected with D-GalN and LPS, but not in mice injected with a high dose of LPS. TNF-α-induced lethal shock in D-GalN-sensitized mice was also protected by pretreatment with flavonoids, suggesting that flavonoids augmented the resistance to TNF-α lethality. On the other hand, flavonoids reduced the plasma level of lipid peroxides in mice injected with a high dose of LPS, but not in D-GalN-sensitized mice. Taken together, these results indicated that flavonoids might protect mice from two types of endotoxin lethality. The protective mechanism of flavonoids in each endotoxin lethality is discussed.

本文言語English
ページ(範囲)29-33
ページ数5
ジャーナルFEMS Immunology and Medical Microbiology
31
1
DOI
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 微生物学
  • 免疫学
  • 微生物学(医療)
  • 感染症

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