Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades

Kazuki Terada, Nobuo Izumo, Biora Suzuki, Yoshiharu Karube, Tomomi Morikawa, Yukiko Ishibashi, Toshiki Kameyama, Koji Chiba, Noriko Sasaki, Keiko Iwata, Hideo Matsuzaki, Takayuki Manabe

研究成果: ジャーナルへの寄稿学術論文査読

16 被引用数 (Scopus)

抄録

Major depression is a complex disorder characterized by genetic and environmental interactions. Selective serotonin reuptake inhibitors (SSRIs) effectively treat depression. Neurogenesis following chronic antidepressant treatment activates brain derived neurotrophic factor (BDNF) signaling. In this study, we analyzed the effects of the SSRI fluvoxamine (Flu) on locomotor activity and forced-swim behavior using chronic dexamethasone (cDEX) infusions in mice, which engenders depression-like behavior. Infusion of cDEX decreased body weight and produced a trend towards lower locomotor activity during darkness. In the forced-swim test, cDEX-mice exhibited increased immobility times compared with mice administered saline. Flu treatment reversed decreased locomotor activity and mitigated forced-swim test immobility. Real-time polymerase chain reactions using brain RNA samples yielded significantly lower BDNF mRNA levels in cDEX-mice compared with the saline group. Endoplasmic reticulum stress-associated X-box binding protein-1 (XBP1) gene expression was lower in cDEX-mice compared with the saline group. However, marked expression of the XBP1 gene was observed in cDEX-mice treated with Flu compared with mice given saline and untreated cDEX-mice. Expression of 5-HT2A and Sigma-1 receptors decreased after cDEX infusion compared with the saline group, and these decreases normalized to control levels upon Flu treatment. Our results indicate that the Flu moderates reductions in voluntary activity following chronic dexamethasone infusions in mice via recovery of BDNF signal cascades.

本文言語英語
ページ(範囲)9-13
ページ数5
ジャーナルNeurochemistry International
69
1
DOI
出版ステータス出版済み - 04-2014

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学

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