Focal macular electroretinogram in X-linked congenital retinoschisis

Y. Miyake, N. Shiroyama, I. Ota, M. Horiguchi

研究成果: Article査読

37 被引用数 (Scopus)


Purpose. To study macular function of X-linked congenital retinoschisis (CRS) by focal macular electroretinogram (MERG). Methods. MERGs were recorded with 5°, 10°, and 15° spots in 20 patients with CRS. Seventeen patients showed foveal schisis with little or no change in foveal fluorescein angiography (Group 1), and three patients showed advanced macular changes with nonspecific macular degeneration (Group 2). Results. In Group 1, a-wave amplitudes were within the normal range, but b-waves and oscillatory potentials (OPs) had mean amplitudes significantly below those for normal control subjects. The mean b- to a-wave ratios, significantly lower than in normal eyes, decreased significantly with decreasing spot size. The implicit times of a-waves, b-waves, and OPs were significantly delayed. In Group 2, MERGs were nearly nondetectable. Conclusions. The macular pathology of CSR exists mainly in the middle and inner retinal layers, disturbing the fovea more than the perifovea, whereas degeneration of photoreceptors progresses in more advanced stage.

ジャーナルInvestigative Ophthalmology and Visual Science
出版ステータスPublished - 30-03-1993

All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学


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