抄録
IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
本文言語 | 英語 |
---|---|
論文番号 | kex171 |
ページ(範囲) | 236-245 |
ページ数 | 10 |
ジャーナル | Rheumatology (United Kingdom) |
巻 | 57 |
号 | 2 |
DOI | |
出版ステータス | 出版済み - 01-02-2018 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- リウマチ学
- 薬理学(医学)