Follicular helper T cells in the pathogenesis of IgG4-related disease

Mitsuhiro Akiyama, Katsuya Suzuki, Hidekata Yasuoka, Yuko Kaneko, Kunihiro Yamaoka, Tsutomu Takeuchi

研究成果: ジャーナルへの寄稿総説査読

76 被引用数 (Scopus)

抄録

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

本文言語英語
論文番号kex171
ページ(範囲)236-245
ページ数10
ジャーナルRheumatology (United Kingdom)
57
2
DOI
出版ステータス出版済み - 01-02-2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • リウマチ学
  • 薬理学(医学)

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