Formation of actin stress fibers and focal adhesions enhanced by Rho- kinase

Mutsuki Amano, Kazuyasu Chihara, Kazushi Kimura, Yuko Fukata, Nao Nakamura, Yoshiharu Matsuura, Kozo Kaibuchi

研究成果: Article査読

931 被引用数 (Scopus)

抄録

The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in fibroblasts stimulated by extracellular signals such as lysophosphatidic acid (LPA). Rho-kinase is activated by Rho and may mediate some biological effects of Rho. Microinjection of the catalytic domain of Rho-kinase into serum-starved Swiss 3T3 cells induced the formation of stress fibers and fOCal adhesions, whereas microinjection of the inactive catalytic domain, the Rho-binding domain, or the pleckstrin-homology domain inhibited the LPA-induced formation of stress fibers and focal adhesions. Thus, Rho-kinase appears to mediate signals from Rho and to induce the formation of stress fibers and focal adhesions.

本文言語English
ページ(範囲)1308-1311
ページ数4
ジャーナルScience
275
5304
DOI
出版ステータスPublished - 28-02-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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