Formation of psammoma bodies in meningocytic whorls - Ultrastructural study and analysis of calcified material

T. Kubota, T. Yamashima, M. Hasegawa, S. Kida, M. Hayashi, S. Yamamoto

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Psammoma bodies in meningocytic whorls were investigated by electron microscopy. In some whorls, connective tissue fibers were seen and membrane-bound vesicles were contiguous to degenerated cells. Some small vesicles, 0.1 to 0.5 μm in diameter, were outlined by plasma membrane (matrix vesicles), other larger ones, about 1 to several μm in diameter, were invested by a thick wall (matrix giant bodies). Mineralized deposits were frequent in these vesicles and occasionally large masses of mineralized connective tissue fibers (psammoma bodies) were seen. Analysis of the material in the mineralized vesicles and fibers, using an energy dispersive X-ray microanalyzer, showed that both calcium and phosphorous were evident and hydroxyapatite was substantiated using an X-ray differactometer. Psammoma body formation in the meningocytic whorls may represent degeneration in some whorls of the central cells which contain connective tissue fibers, producing cell debris such as membrane invested vesicles. Subsequently, calcification occurs in these vesicles, and the mineralization process extends to neighboring connective tissue fibers. The calcified mass forms a psammoma body.

本文言語English
ページ(範囲)262-268
ページ数7
ジャーナルActa Neuropathologica
70
3-4
DOI
出版ステータスPublished - 09-1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 臨床神経学
  • 細胞および分子神経科学

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