Four cases of anal squamous cell carcinoma treated by chemoradiotherapy

Harunobu Sato, Koutarou Maeda, Yoshikazu Koide, Hiroshi Matsuoka, Tomohito Noro, Katsuyuki Honda, Miho Shiota, Tomoyoshi Endo, Shinji Ozeki, Masayoshi Fukuda

研究成果: ジャーナルへの寄稿学術論文査読


We reviewed clinical records of 4 cases with squamous cell carcinoma in anus to evaluate the clinical effectiveness of the chemoradiotherapy. The radiation therapy consisted of 40 Gy was delivered to pelvis and bilateral inguinal lesion, and perianal booster dose of 20 Gy, in fractions of 2.0 Gy per day, was given five days a week. On the first day of radiation therapy, 750mg/m2 of 5-FU in the form of a continuous 24-hour infusion for 5 days was given. On the first day of chemotherapy, 10mg/m2 of MMC was also given as a single bolus infusion. 5-FU and MMC were administered 4 times every 4 weeks. Three patients had T2 tumor, and one patient had T1 tumor. One patient had metastases in para-aortic and Virchow lymph node. No patients had hematogenous metastases. Grade 1 or 2 adverse effects occurred in 3 patients during chemoradiotherapy, but the completion of chemoradiotherpy was achieved in all of the 4 patients. All patients had complete response in the anal lesion after chemoradiotherapy. No patients had any sign of recurrence in anal lesion. Chemoradiotherapy was expected to be a safe and effective treatment to improve prognosis for anal squamous carcinoma.

ジャーナルJapanese Journal of Cancer and Chemotherapy
出版ステータス出版済み - 11-2010

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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