Frequent altered expression of fragile histidine triad protein in human colorectal adenomas

Hiroshi Morikawa, Yoshihito Nakagawa, Keisuke Hashimoto, Masami Niki, Yutaro Egashira, Ichiro Hirata, Kenichi Katsu, Yukihiro Akao

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Fragile histidine triad (FHIT) gene is involved in deletions on the short arm of chromosome 3 in various human cancers. We found that 47% of colorectal adenomas, which is a higher frequency than that of K-ras, showed altered expression of the Fhit protein by Western blot analysis. The amount of Fhit protein was inversely correlated with the degree of dysplasia. Importantly, 27% of low-grade dysplastic adenomas showed altered expression of Fhit protein. Additionally, expression of human Fhit protein in human colon carcinoma cell line SW480 exhibited a marked inhibition of growth and rendered SW480 cells highly susceptible to undergo apoptosis compared with control cells. These findings suggest that altered expression of the FHIT gene is a quite early aberration in the development of colorectal tumors and that Fhit protein may act as a tumor suppressor. (C) 2000 Academic Press.

本文言語English
ページ(範囲)205-210
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
278
1
DOI
出版ステータスPublished - 11-11-2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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