Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases

Shu Kato, Motoi Yanazaki, Kino Hayashi, Fumiko Satoh, Ichiro Isobe, Yutaka Tsutsumi

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2–4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic autopsy cases were young (24–38 years-old) with the mean age of 32, and the primary infective lesions were located in the postpartum endometrium, tonsil and bronchus (2 cases). Systemic coccal dissemination with poor neutrophilic reaction was seen in two of five cases. Bilateral renal cortical necrosis was noted in three cases (including two with bacterial embolism). Hemophagocytosis, probably resulting from hypercytokinemia, was characteristic in three cases without bacterial embolism. Gram-positive cocci colonizing the hemorrhagic and necrotizing lesions were consistently immunoreactive for streptococcal antigens and Strep A (a carbohydrate antigen on group A streptococci). Neutrophilic reaction was mild in the primary infected foci. Clinicians should note that fulminant streptococcal infection (streptococcal toxic shock syndrome) in young and immunocompetent patients may not be associated with gangrene in the extremities. Autopsy prosecutors (diagnostic and forensic pathologists) must recognize the difficulty in making an appropriate autopsy diagnosis, particularly when bacterial embolism is not associated.

本文言語英語
ページ(範囲)419-424
ページ数6
ジャーナルPathology International
68
7
DOI
出版ステータス出版済み - 07-2018

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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