Function of a cell adhesion molecule, plexin, in neuron network formation

Hajime Fujisawa, Kunimasa Ohta, Toshiki Kameyama, Yasunori Murakami

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

本文言語English
ページ(範囲)101-105
ページ数5
ジャーナルDevelopmental Neuroscience
19
1
DOI
出版ステータスPublished - 01-01-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 発達神経科学

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