Function of a cell adhesion molecule, plexin, in neuron network formation

Hajime Fujisawa, Kunimasa Ohta, Toshiki Kameyama, Yasunori Murakami

研究成果: Article

18 引用 (Scopus)

抄録

Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

元の言語English
ページ(範囲)101-105
ページ数5
ジャーナルDevelopmental Neuroscience
19
発行部数1
DOI
出版物ステータスPublished - 01-01-1997

Fingerprint

Cell Adhesion Molecules
Neurons
Xenopus
Cysteine
Proto-Oncogene Proteins
Cell Aggregation
Oncogene Proteins
Hybridomas
Molecular Cloning
Cell Adhesion
Nervous System
Membrane Proteins
Proteins
plexin
Ions
Calcium

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

これを引用

Fujisawa, Hajime ; Ohta, Kunimasa ; Kameyama, Toshiki ; Murakami, Yasunori. / Function of a cell adhesion molecule, plexin, in neuron network formation. :: Developmental Neuroscience. 1997 ; 巻 19, 番号 1. pp. 101-105.
@article{c4abb9242252444582e02f071856d20c,
title = "Function of a cell adhesion molecule, plexin, in neuron network formation",
abstract = "Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.",
author = "Hajime Fujisawa and Kunimasa Ohta and Toshiki Kameyama and Yasunori Murakami",
year = "1997",
month = "1",
day = "1",
doi = "10.1159/000111192",
language = "English",
volume = "19",
pages = "101--105",
journal = "Developmental Neuroscience",
issn = "0378-5866",
publisher = "S. Karger AG",
number = "1",

}

Function of a cell adhesion molecule, plexin, in neuron network formation. / Fujisawa, Hajime; Ohta, Kunimasa; Kameyama, Toshiki; Murakami, Yasunori.

:: Developmental Neuroscience, 巻 19, 番号 1, 01.01.1997, p. 101-105.

研究成果: Article

TY - JOUR

T1 - Function of a cell adhesion molecule, plexin, in neuron network formation

AU - Fujisawa, Hajime

AU - Ohta, Kunimasa

AU - Kameyama, Toshiki

AU - Murakami, Yasunori

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

AB - Plexin is a type I membrane protein which was identified in Xenopus nervous system by hybridoma technique. Molecular cloning studies demonstrated that the extracellular segment of the plexin protein possesses three internal repeats of cysteine cluster which are homologous to the cysteine-rich domain of the omet proto-oncogene protein product. A cell aggregation test revealed that the plexin protein mediated cell adhesion via a homophilic binding mechanism, in the presence of calcium ions. Plexin was expressed in the neuronal elements composing particular neuron circuits in Xenopus CNS and PNS. These findings indicate that plexin is a new member of the Ca2+-dependent cell adhesion molecules, and suggest that the molecule plays an important role in neuronal cell contact and neuron network formation.

UR - http://www.scopus.com/inward/record.url?scp=0031053078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031053078&partnerID=8YFLogxK

U2 - 10.1159/000111192

DO - 10.1159/000111192

M3 - Article

C2 - 9078440

AN - SCOPUS:0031053078

VL - 19

SP - 101

EP - 105

JO - Developmental Neuroscience

JF - Developmental Neuroscience

SN - 0378-5866

IS - 1

ER -