Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

Masatoshi Hirayama, Miho Ogawa, Masamitsu Oshima, Yurie Sekine, Kentaro Ishida, Kentaro Yamashita, Kazutaka Ikeda, Shigeto Shimmura, Tetsuya Kawakita, Kazuo Tsubota, Takashi Tsuji

研究成果: ジャーナルへの寄稿学術論文査読

126 被引用数 (Scopus)

抄録

The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic transplantation of bioengineered lacrimal gland germs into adult mice with an extra-orbital lacrimal gland defect, a mouse model that mimics the corneal epithelial damage caused by lacrimal gland dysfunction. The bioengineered lacrimal gland germs and harderian gland germs both develop in vivo and achieve sufficient physiological functionality, including tear production in response to nervous stimulation and ocular surface protection. This study demonstrates the potential for bioengineered organ replacement to functionally restore the lacrimal gland.

本文言語英語
論文番号2497
ジャーナルNature communications
4
DOI
出版ステータス出版済み - 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学一般
  • 生化学、遺伝学、分子生物学一般
  • 物理学および天文学一般

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