GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung Chun Kim, Kiyofumi Yamada

研究成果: Article査読

41 被引用数 (Scopus)

抄録

In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABAA receptor agonist, had no significant effect. GABAB receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.

本文言語English
ページ(範囲)101-104
ページ数4
ジャーナルEuropean Journal of Pharmacology
602
1
DOI
出版ステータスPublished - 05-01-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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