TY - JOUR
T1 - Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice
AU - Koseki, Takenao
AU - Mouri, Akihiro
AU - Suzuki, Shizuka
AU - Nakajima, Azusa
AU - Mamiya, Takayoshi
AU - Yan, Yijin
AU - Nabeshima, Toshitaka
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior. Methamphetamine (METH) dependence is becoming a serious problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.
AB - Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior. Methamphetamine (METH) dependence is becoming a serious problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.
UR - http://www.scopus.com/inward/record.url?scp=84890806316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890806316&partnerID=8YFLogxK
U2 - 10.1111/j.1369-1600.2011.00425.x
DO - 10.1111/j.1369-1600.2011.00425.x
M3 - Article
C2 - 22260318
AN - SCOPUS:84890806316
SN - 1355-6215
VL - 19
SP - 1
EP - 4
JO - Addiction Biology
JF - Addiction Biology
IS - 1
ER -
