Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice

Takenao Koseki, Akihiro Mouri, Shizuka Suzuki, Azusa Nakajima, Takayoshi Mamiya, Yijin Yan, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)

抄録

Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior. Methamphetamine (METH) dependence is becoming a serious problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.

本文言語英語
ページ(範囲)1-4
ページ数4
ジャーナルAddiction Biology
19
1
DOI
出版ステータス出版済み - 01-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 薬理学
  • 精神医学および精神衛生

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