Gastric acid reduction leads to an alteration in lower intestinal microflora

Takayuki Kanno, Takahiro Matsuki, Masashi Oka, Hirotoshi Utsunomiya, Kenichi Inada, Hirohito Magari, Izumi Inoue, Takao Maekita, Kazuki Ueda, Shotaro Enomoto, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyuki Tamai, Shigeru Akimoto, Koji Nomoto, Ryuichiro Tanaka, Masao Ichinose

研究成果: Article査読

69 被引用数 (Scopus)

抄録

To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptomatic human subjects with hypochlorhydria. In both rat and human experiments, most genera or groups of intestinal microflora (facultative and obligate anaerobes) proliferated by gastric acid reduction, and marked and significant increases in the Lactobacilli group and Veillonella, oropharyngeal bacteria, were observed. In rats, potent gastric acid inhibition led to a marked and significant increase of intestinal bacteria, including the Bacteroides fragilis group, while Bifidobacterium, a beneficial bacterial species, remained at a constant level. These results strongly indicate that the gastric acid barrier not only controls the colonization and growth of oropharyngeal bacteria, but also regulates the population and composition of lower intestinal microflora.

本文言語English
ページ(範囲)666-670
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
381
4
DOI
出版ステータスPublished - 17-04-2009

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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