Gastric cancer and eradication of H. pylori

Diagnosis and treatment of gastric cancer has now been established, and prevention is thought to be of importance to overcome this disease. Many experimental and clinical researches have clarified the pivotal role of H. pylori infection in gastric carcinogenesis. Therefore, prevention of gastric carcinogenesis by H. pylori eradication seems to be promising, and the possibility has been suggested by experimental and clinical studies. The issues to be solved are to select the candidates for eradication and to assess the timing of eradication. Development of new diagnostic methods and biomarkers for H. pylori eradication is required.