Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Urano, Tetsuya Tsukamoto, Makoto Kuroda, Naoki Ohmiya

研究成果: Article

抄録

To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

元の言語English
ページ(範囲)417-426
ページ数10
ジャーナルCancer Investigation
37
発行部数9
DOI
出版物ステータスPublished - 21-10-2019

Fingerprint

MicroRNAs
Helicobacter pylori
Stomach
Down-Regulation
Narrow Band Imaging
Metaplasia
Gastric Mucosa
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Tahara, Tomomitsu ; Tahara, Sayumi ; Horiguchi, Noriyuki ; Kawamura, Tomohiko ; Okubo, Masaaki ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Urano, Makoto ; Tsukamoto, Tetsuya ; Kuroda, Makoto ; Ohmiya, Naoki. / Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. :: Cancer Investigation. 2019 ; 巻 37, 番号 9. pp. 417-426.
@article{91e988b22c7c4cf9ae0b52b0ccaa275d,
title = "Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a",
abstract = "To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.",
author = "Tomomitsu Tahara and Sayumi Tahara and Noriyuki Horiguchi and Tomohiko Kawamura and Masaaki Okubo and Mitsuo Nagasaka and Yoshihito Nakagawa and Tomoyuki Shibata and Makoto Urano and Tetsuya Tsukamoto and Makoto Kuroda and Naoki Ohmiya",
year = "2019",
month = "10",
day = "21",
doi = "10.1080/07357907.2019.1663207",
language = "English",
volume = "37",
pages = "417--426",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "9",

}

Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. / Tahara, Tomomitsu; Tahara, Sayumi; Horiguchi, Noriyuki; Kawamura, Tomohiko; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Urano, Makoto; Tsukamoto, Tetsuya; Kuroda, Makoto; Ohmiya, Naoki.

:: Cancer Investigation, 巻 37, 番号 9, 21.10.2019, p. 417-426.

研究成果: Article

TY - JOUR

T1 - Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

AU - Tahara, Tomomitsu

AU - Tahara, Sayumi

AU - Horiguchi, Noriyuki

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Shibata, Tomoyuki

AU - Urano, Makoto

AU - Tsukamoto, Tetsuya

AU - Kuroda, Makoto

AU - Ohmiya, Naoki

PY - 2019/10/21

Y1 - 2019/10/21

N2 - To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

AB - To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

UR - http://www.scopus.com/inward/record.url?scp=85073581327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073581327&partnerID=8YFLogxK

U2 - 10.1080/07357907.2019.1663207

DO - 10.1080/07357907.2019.1663207

M3 - Article

C2 - 31483161

AN - SCOPUS:85073581327

VL - 37

SP - 417

EP - 426

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 9

ER -