Gender differences in the clinical features of sleep apnea syndrome

Yuki Mieno, Masamichi Hayashi, Hiroki Sakakibara, Hiroshi Takahashi, Shiho Fujita, Sumito Isogai, Yasuhiro Goto, Sakurako Uozu, Mitsushi Okazawa, Kazuyoshi Imaizumi

研究成果: Article

2 引用 (Scopus)

抄録

Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders. Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS. Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0% vs. 35.2%). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities. Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.

元の言語English
ページ(範囲)2157-2163
ページ数7
ジャーナルInternal Medicine
57
発行部数15
DOI
出版物ステータスPublished - 01-01-2018

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Sleep Apnea Syndromes
Apnea
Logistic Models
Regression Analysis
Polysomnography
Hyperlipidemias
Hemoglobins
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Mieno, Y., Hayashi, M., Sakakibara, H., Takahashi, H., Fujita, S., Isogai, S., ... Imaizumi, K. (2018). Gender differences in the clinical features of sleep apnea syndrome. Internal Medicine, 57(15), 2157-2163. https://doi.org/10.2169/internalmedicine.7570-16
Mieno, Yuki ; Hayashi, Masamichi ; Sakakibara, Hiroki ; Takahashi, Hiroshi ; Fujita, Shiho ; Isogai, Sumito ; Goto, Yasuhiro ; Uozu, Sakurako ; Okazawa, Mitsushi ; Imaizumi, Kazuyoshi. / Gender differences in the clinical features of sleep apnea syndrome. :: Internal Medicine. 2018 ; 巻 57, 番号 15. pp. 2157-2163.
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title = "Gender differences in the clinical features of sleep apnea syndrome",
abstract = "Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders. Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS. Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0{\%} vs. 35.2{\%}). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities. Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.",
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Mieno, Y, Hayashi, M, Sakakibara, H, Takahashi, H, Fujita, S, Isogai, S, Goto, Y, Uozu, S, Okazawa, M & Imaizumi, K 2018, 'Gender differences in the clinical features of sleep apnea syndrome', Internal Medicine, 巻. 57, 番号 15, pp. 2157-2163. https://doi.org/10.2169/internalmedicine.7570-16

Gender differences in the clinical features of sleep apnea syndrome. / Mieno, Yuki; Hayashi, Masamichi; Sakakibara, Hiroki; Takahashi, Hiroshi; Fujita, Shiho; Isogai, Sumito; Goto, Yasuhiro; Uozu, Sakurako; Okazawa, Mitsushi; Imaizumi, Kazuyoshi.

:: Internal Medicine, 巻 57, 番号 15, 01.01.2018, p. 2157-2163.

研究成果: Article

TY - JOUR

T1 - Gender differences in the clinical features of sleep apnea syndrome

AU - Mieno, Yuki

AU - Hayashi, Masamichi

AU - Sakakibara, Hiroki

AU - Takahashi, Hiroshi

AU - Fujita, Shiho

AU - Isogai, Sumito

AU - Goto, Yasuhiro

AU - Uozu, Sakurako

AU - Okazawa, Mitsushi

AU - Imaizumi, Kazuyoshi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders. Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS. Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0% vs. 35.2%). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities. Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.

AB - Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders. Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS. Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0% vs. 35.2%). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities. Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.

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Mieno Y, Hayashi M, Sakakibara H, Takahashi H, Fujita S, Isogai S その他. Gender differences in the clinical features of sleep apnea syndrome. Internal Medicine. 2018 1 1;57(15):2157-2163. https://doi.org/10.2169/internalmedicine.7570-16