Gene expression in pulmonary fibrosis

Eileen Hsu, Hidekata Yasuoka, Carol A. Feghali-Bostwick

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

Pulmonary fibrosis is a phenotype that results from a variety of conditions and is associated with significant morbidity and mortality. Ongoing research in the field is driven by the need for effective treatments for pulmonary fibrosis. In this review, we highlight mechanisms that regulate gene expression in pulmonary fibrosis at multiple levels. Potential pathogenic mechanisms involve genetic background and transcriptional, posttranscriptional, translational, posttranslational, and epigenetic mechanisms. Pulmonary fibrosis results from abnormal gene expression and regulation that arise from a combination of inherited/acquired genetic alterations and environmental triggers. Collectively, these alterations result in increased expression of extracellular matrix components such as collagen and fibronectin and in the observed fibrosis. Insights gained from mechanisms identified to induce and/or perpetuate fibrosis in the lung will yield new targets for the development of more effective therapies.

本文言語English
ページ(範囲)47-56
ページ数10
ジャーナルCritical Reviews in Eukaryotic Gene Expression
18
1
DOI
出版ステータスPublished - 01-01-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学

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