Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Branko Aleksic, Itaru Kushima, Yoshihito Ito, Yukako Nakamura, Hiroshi Ujike, Michio Suzuki, Toshiya Inada, Ryota Hashimoto, Masatoshi Takeda, Nakao Iwata, Norio Ozaki

研究成果: Article

11 引用 (Scopus)

抄録

The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

元の言語English
ページ(範囲)113-117
ページ数5
ジャーナルSchizophrenia Research
118
発行部数1-3
DOI
出版物ステータスPublished - 01-05-2010

Fingerprint

Genetic Association Studies
Schizophrenia
Population
Wnt Signaling Pathway
Genetic Promoter Regions
Genes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Aleksic, B., Kushima, I., Ito, Y., Nakamura, Y., Ujike, H., Suzuki, M., ... Ozaki, N. (2010). Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophrenia Research, 118(1-3), 113-117. https://doi.org/10.1016/j.schres.2010.01.014
Aleksic, Branko ; Kushima, Itaru ; Ito, Yoshihito ; Nakamura, Yukako ; Ujike, Hiroshi ; Suzuki, Michio ; Inada, Toshiya ; Hashimoto, Ryota ; Takeda, Masatoshi ; Iwata, Nakao ; Ozaki, Norio. / Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. :: Schizophrenia Research. 2010 ; 巻 118, 番号 1-3. pp. 113-117.
@article{5c51904d480a44dfa531be70a030374e,
title = "Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population",
abstract = "The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.",
author = "Branko Aleksic and Itaru Kushima and Yoshihito Ito and Yukako Nakamura and Hiroshi Ujike and Michio Suzuki and Toshiya Inada and Ryota Hashimoto and Masatoshi Takeda and Nakao Iwata and Norio Ozaki",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/j.schres.2010.01.014",
language = "English",
volume = "118",
pages = "113--117",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

Aleksic, B, Kushima, I, Ito, Y, Nakamura, Y, Ujike, H, Suzuki, M, Inada, T, Hashimoto, R, Takeda, M, Iwata, N & Ozaki, N 2010, 'Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population', Schizophrenia Research, 巻. 118, 番号 1-3, pp. 113-117. https://doi.org/10.1016/j.schres.2010.01.014

Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. / Aleksic, Branko; Kushima, Itaru; Ito, Yoshihito; Nakamura, Yukako; Ujike, Hiroshi; Suzuki, Michio; Inada, Toshiya; Hashimoto, Ryota; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio.

:: Schizophrenia Research, 巻 118, 番号 1-3, 01.05.2010, p. 113-117.

研究成果: Article

TY - JOUR

T1 - Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

AU - Aleksic, Branko

AU - Kushima, Itaru

AU - Ito, Yoshihito

AU - Nakamura, Yukako

AU - Ujike, Hiroshi

AU - Suzuki, Michio

AU - Inada, Toshiya

AU - Hashimoto, Ryota

AU - Takeda, Masatoshi

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2010/5/1

Y1 - 2010/5/1

N2 - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

AB - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=77951976760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951976760&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2010.01.014

DO - 10.1016/j.schres.2010.01.014

M3 - Article

VL - 118

SP - 113

EP - 117

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -