抄録
Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 375-383 |
| ページ数 | 9 |
| ジャーナル | Neuropsychiatric Disease and Treatment |
| 巻 | 15 |
| DOI | |
| 出版物ステータス | Published - 01-01-2019 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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Genetic effects on white matter integrity in drug-naive patients with major depressive disorder : A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms. / Kakeda, Shingo; Watanabe, Keita; Katsuki, Asuka; Sugimoto, Koichiro; Ueda, Issei; Igata, Natsuki; Kishi, Taro; Iwata, Nakao; Abe, Osamu; Yoshimura, Reiji; Korogi, Yukunori.
：: Neuropsychiatric Disease and Treatment, 巻 15, 01.01.2019, p. 375-383.研究成果: Article
TY - JOUR
T1 - Genetic effects on white matter integrity in drug-naive patients with major depressive disorder
T2 - A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms
AU - Kakeda, Shingo
AU - Watanabe, Keita
AU - Katsuki, Asuka
AU - Sugimoto, Koichiro
AU - Ueda, Issei
AU - Igata, Natsuki
AU - Kishi, Taro
AU - Iwata, Nakao
AU - Abe, Osamu
AU - Yoshimura, Reiji
AU - Korogi, Yukunori
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.
AB - Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.
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U2 - 10.2147/NDT.S190268
DO - 10.2147/NDT.S190268
M3 - Article
AN - SCOPUS:85062673603
VL - 15
SP - 375
EP - 383
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
SN - 1176-6328
ER -