@article{1e1823ab3a97441ca4b27076bbbb6420,
title = "Genetic studies of body mass index yield new insights for obesity biology",
abstract = "Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.",
author = "{Lifelines Cohort Study} and {ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium} and Locke, {A. E.} and B. Kahali and Berndt, {S. I.} and Justice, {A. E.} and Pers, {T. H.} and Day, {F. R.} and C. Powell and S. Vedantam and Buchkovich, {M. L.} and J. Yang and Croteau-Chonka, {D. C.} and T. Esko and T. Fall and T. Ferreira and S. Gustafsson and Z. Kutalik and J. Luan and R. M{\"a}gi and Randall, {J. C.} and Winkler, {T. W.} and Wood, {A. R.} and T. Workalemahu and Faul, {J. D.} and Smith, {J. A.} and Zhao, {J. H.} and W. Zhao and J. Chen and R. Fehrmann and K. Hedman and J. Karjalainen and Schmidt, {E. M.} and D. Absher and N. Amin and D. Anderson and M. Beekman and Bolton, {J. L.} and Bragg-Gresham, {J. L.} and S. Buyske and A. Demirkan and G. Deng and Ehret, {G. B.} and B. Feenstra and Feitosa, {M. F.} and K. Fischer and A. Goel and J. Gong and Jackson, {A. U.} and S. Kanoni and Kleber, {M. E.} and M. Kubo",
note = "Funding Information: 249Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. 250Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK. 251Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. 252Centre forCardiovascularGenetics,Institute CardiovascularSciences,UniversityCollegeLondon, London WC1E 6JJ, UK. 253Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA. 254Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia. 255School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia. 256South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia. 257Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK. 258Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany. 259National Institute for Health and Welfare, FI-90101 Oulu, Finland. 260MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK. 261Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland. 262Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland. 263Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.264Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands. 265Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands. 266Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland.267Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. 268Imperial College Healthcare NHS Trust, London W12 0HS, UK. 269Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK. 270Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. 271Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland. 272Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland.",
year = "2015",
month = feb,
day = "12",
doi = "10.1038/nature14177",
language = "English",
volume = "518",
pages = "197--206",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7538",
}