@article{1e1823ab3a97441ca4b27076bbbb6420,
title = "Genetic studies of body mass index yield new insights for obesity biology",
abstract = "Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.",
author = "{Lifelines Cohort Study} and {ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium} and Locke, {A. E.} and B. Kahali and Berndt, {S. I.} and Justice, {A. E.} and Pers, {T. H.} and Day, {F. R.} and C. Powell and S. Vedantam and Buchkovich, {M. L.} and J. Yang and Croteau-Chonka, {D. C.} and T. Esko and T. Fall and T. Ferreira and S. Gustafsson and Z. Kutalik and J. Luan and R. M{\"a}gi and Randall, {J. C.} and Winkler, {T. W.} and Wood, {A. R.} and T. Workalemahu and Faul, {J. D.} and Smith, {J. A.} and Zhao, {J. H.} and W. Zhao and J. Chen and R. Fehrmann and K. Hedman and J. Karjalainen and Schmidt, {E. M.} and D. Absher and N. Amin and D. Anderson and M. Beekman and Bolton, {J. L.} and Bragg-Gresham, {J. L.} and S. Buyske and A. Demirkan and G. Deng and Ehret, {G. B.} and B. Feenstra and Feitosa, {M. F.} and K. Fischer and A. Goel and J. Gong and Jackson, {A. U.} and S. Kanoni and Kleber, {M. E.} and M. Kubo",
note = "Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved.",
year = "2015",
month = feb,
day = "12",
doi = "10.1038/nature14177",
language = "English",
volume = "518",
pages = "197--206",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7538",
}