TY - JOUR
T1 - Genome-wide association studies for pelvic organ prolapse in the Japanese population
AU - the BioBank Japan Project
AU - Matsunami, Masatoshi
AU - Imamura, Minako
AU - Ashikari, Asuka
AU - Liu, Xiaoxi
AU - Tomizuka, Kohei
AU - Hikino, Keiko
AU - Miwa, Kosei
AU - Kadekawa, Katsumi
AU - Suda, Tetsuji
AU - Koretsune, Yukihiro
AU - Koga, Yoshinobu
AU - Masumoto, Akihide
AU - Higashiyama, Masahiko
AU - Obata, Daisuke
AU - Miki, Yoshio
AU - Yoshimori, Kozo
AU - Murayama, Shigeo
AU - Iwasaki, Yu Ki
AU - Nito, Chikako
AU - Wakita, Satoshi
AU - Nagata, Yasunobu
AU - Yamaguchi, Hiroki
AU - Kobayashi, Shuzo
AU - Higashiue, Shinichi
AU - Takahashi, Yasuo
AU - Asai, Satoshi
AU - Takahash, Kazuhisa
AU - Yamaji, Ken
AU - Obara, Wataru
AU - Nakamura, Yusuke
AU - Murakami, Yoshinori
AU - Yamanashi, Yuji
AU - Furukawa, Yoichi
AU - Kumasaka, Natsuhiko
AU - Sagiya, Yoji
AU - Nagai, Akiko
AU - Muto, Kaori
AU - Kamatani, Yoichiro
AU - Okada, Yukinori
AU - Morisaki, Takayuki
AU - Matsuda, Koichi
AU - Miyazato, Minoru
AU - Terao, Chikashi
AU - Maeda, Shiro
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29–1.68, P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data and previously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2 locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04–1.08, P = 4.11 × 10−8). We also observed consistent directions of the effects for 21 out of 24 European GWAS derived loci (binomial test P = 2.8 × 10−4), indicating that most of susceptibility loci for POP are shared across the Japanese and European populations.
AB - Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29–1.68, P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data and previously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2 locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04–1.08, P = 4.11 × 10−8). We also observed consistent directions of the effects for 21 out of 24 European GWAS derived loci (binomial test P = 2.8 × 10−4), indicating that most of susceptibility loci for POP are shared across the Japanese and European populations.
UR - https://www.scopus.com/pages/publications/85205447073
UR - https://www.scopus.com/pages/publications/85205447073#tab=citedBy
U2 - 10.1038/s42003-024-06875-2
DO - 10.1038/s42003-024-06875-2
M3 - Article
C2 - 39349682
AN - SCOPUS:85205447073
SN - 2399-3642
VL - 7
JO - Communications biology
JF - Communications biology
IS - 1
M1 - 1188
ER -