Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Ryo Takata, Shusuke Akamatsu, Michiaki Kubo, Atsushi Takahashi, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Johji Inazawa, Naoyuki Kamatani, Osamu Ogawa, Tomoaki Fujioka, Yusuke Nakamura, Hidewaki Nakagawa

研究成果: Letter

212 引用 (Scopus)

抜粋

Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability PGC = 3.9 x 10-18), GPRC6A/RFX6 (PGC = 1.6 x 10-12), 13q22 (PGC = 2.8 x 10-9), C2orf43 (PGC = 7.5 x 10-8) and FOXP4 (PGC = 7.6 x 10-8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

元の言語English
ページ(範囲)751-755
ページ数5
ジャーナルNature Genetics
42
発行部数9
DOI
出版物ステータスPublished - 01-01-2010

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Takata, R., Akamatsu, S., Kubo, M., Takahashi, A., Hosono, N., Kawaguchi, T., Tsunoda, T., Inazawa, J., Kamatani, N., Ogawa, O., Fujioka, T., Nakamura, Y., & Nakagawa, H. (2010). Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nature Genetics, 42(9), 751-755. https://doi.org/10.1038/ng.635