Genomic analysis of ossification of the posterior longitudinal ligament

Takashi Tsuji

Genomic analysis of ossification of the posterior longitudinal ligament

Takashi Tsuji

研究成果: ジャーナルへの寄稿 › 総説 › 査読

抄録

OPLL is considered as a multi-factorial disease influenced by genetic and environmental factors. To identify genetic factors for OPLL, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligament performed a genome-wide association study(GWAS)using 1,660 OPLL patients. The study group identified six susceptibility loci for OPLL:20p12.3(rs2423294:P= 1.10 × 10(-13)), 8q23.1(rs374810:P= 1.88 × 10(-13)),12p11.22(rs1979679:P= 4.34 × 10(-12)), 12p12.2(rs11045000:P= 2.95 × 10(-11)),8q23.3(rs13279799:P= 1.28 × 10(-10))and 6p21.1(rs927485:P= 9.40 × 10(-9)).A further functional study for the susceptibility loci should aid in clarification of etiology of OPLL.

本文言語	英語
ページ（範囲）	545-552
ページ数	8
ジャーナル	Clinical calcium
巻	26
号	4
出版ステータス	出版済み - 01-04-2016
外部発表	はい

All Science Journal Classification (ASJC) codes

医学一般

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title = "Genomic analysis of ossification of the posterior longitudinal ligament",

abstract = "OPLL is considered as a multi-factorial disease influenced by genetic and environmental factors. To identify genetic factors for OPLL, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligament performed a genome-wide association study(GWAS)using 1,660 OPLL patients. The study group identified six susceptibility loci for OPLL:20p12.3(rs2423294:P= 1.10 × 10(-13)), 8q23.1(rs374810:P= 1.88 × 10(-13)),12p11.22(rs1979679:P= 4.34 × 10(-12)), 12p12.2(rs11045000:P= 2.95 × 10(-11)),8q23.3(rs13279799:P= 1.28 × 10(-10))and 6p21.1(rs927485:P= 9.40 × 10(-9)).A further functional study for the susceptibility loci should aid in clarification of etiology of OPLL. ",

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T1 - Genomic analysis of ossification of the posterior longitudinal ligament

AU - Tsuji, Takashi

PY - 2016/4/1

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N2 - OPLL is considered as a multi-factorial disease influenced by genetic and environmental factors. To identify genetic factors for OPLL, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligament performed a genome-wide association study(GWAS)using 1,660 OPLL patients. The study group identified six susceptibility loci for OPLL:20p12.3(rs2423294:P= 1.10 × 10(-13)), 8q23.1(rs374810:P= 1.88 × 10(-13)),12p11.22(rs1979679:P= 4.34 × 10(-12)), 12p12.2(rs11045000:P= 2.95 × 10(-11)),8q23.3(rs13279799:P= 1.28 × 10(-10))and 6p21.1(rs927485:P= 9.40 × 10(-9)).A further functional study for the susceptibility loci should aid in clarification of etiology of OPLL.

AB - OPLL is considered as a multi-factorial disease influenced by genetic and environmental factors. To identify genetic factors for OPLL, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligament performed a genome-wide association study(GWAS)using 1,660 OPLL patients. The study group identified six susceptibility loci for OPLL:20p12.3(rs2423294:P= 1.10 × 10(-13)), 8q23.1(rs374810:P= 1.88 × 10(-13)),12p11.22(rs1979679:P= 4.34 × 10(-12)), 12p12.2(rs11045000:P= 2.95 × 10(-11)),8q23.3(rs13279799:P= 1.28 × 10(-10))and 6p21.1(rs927485:P= 9.40 × 10(-9)).A further functional study for the susceptibility loci should aid in clarification of etiology of OPLL.

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M3 - Review article

C2 - 27013624

AN - SCOPUS:84984788949

SN - 0917-5857

VL - 26

SP - 545

EP - 552

JO - Clinical calcium

JF - Clinical calcium

IS - 4

ER -

Genomic analysis of ossification of the posterior longitudinal ligament

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