Genotypes and infection sites in an outbreak of multidrug-resistant Pseudomonas aeruginosa

A. Tsutsui, S. Suzuki, K. Yamane, M. Matsui, T. Konda, E. Marui, K. Takahashi, Y. Arakawa

研究成果: ジャーナルへの寄稿学術論文査読

27 被引用数 (Scopus)

抄録

An outbreak of multidrug-resistant (MDR) Pseudomonas aeruginosa occurred in an acute care hospital in Japan, which lasted for more than three years. During January 2006 to June 2009, 59 hospitalised patients with MDR P. aeruginosa were mainly detected by urine culture in the first half, whereas isolation from respiratory tract samples became dominant in the latter half of the outbreak. Non-duplicate MDR P. aeruginosa isolates were available from 51 patients and all isolates were positive for blaVIM-2. Pulsed-field gel electrophoresis (PFGE) analysis categorised the isolates into three major clusters; types A, B and C with eight, 19 and 21 isolates, respectively. The outbreak started with patients harbouring PFGE type A strains, followed by type B, and type C strains. Multivariate analysis demonstrated that patients with PFGE type C strains were more likely to be detected by respiratory tract samples (odds ratio: 11.87; 95% confidence interval: 1.21-116.86). Improved aseptic urethral catheter care controlled PFGE type A and type B strains and improvement in respiratory care procedures finally contained the transmission of PFGE type C strains.

本文言語英語
ページ(範囲)317-322
ページ数6
ジャーナルJournal of Hospital Infection
78
4
DOI
出版ステータス出版済み - 08-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 感染症

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