Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: A prospective randomized placebo-controlled double-blind cross-over study

Yasumasa Niwa, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Osamu Watanabe, Takafumi Ando, Hiroki Kawashima, Akihiro Itoh, Yoshiki Hirooka, Hidemi Goto

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Background and Aims: Little information is available regarding the prevention and treatment of small intestinal mucosal injuries caused by non-steroidal anti-inflammatory drugs (NSAIDs). We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE). Subjects and Methods: Ten healthy male volunteers took oral GGA 300 mg/day (regimen A) or placebo (regimen B) in addition to diclofenac 75 mg/day + rabeprazole 20 mg/day for 7 days. We conducted a cross-over trial of regimens A and B with a 2-week washout period. All subjects underwent VCE before and after each administration period, and were evaluated for NSAID-induced gastric and small intestinal mucosal lesions. Results: The number of mucosal lesions (erosions, ulcers and a red spot with possible bleeding) detected in both stomach and small bowel changed between prior to and immediately after administration period, with significantly fewer lesions for regimen A after administration period (mean ± SD A:B = 2.6 ± 3.2:9.5 ± 8.5; p = 0.027). Conclusions: Combination therapy with GGA and rabeprazole reduced the incidence of gastroenteropathy induced by 1-week administration of diclofenac. Our findings suggest this therapy as a candidate for protecting patients on long-term NSAID therapy.

本文言語English
ページ(範囲)260-266
ページ数7
ジャーナルDigestion
80
4
DOI
出版ステータスPublished - 12-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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