TY - JOUR
T1 - Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium
AU - Tanaka, Hiromasa
AU - Mizuno, Masaaki
AU - Ishikawa, Kenji
AU - Takeda, Keigo
AU - Hashizume, Hiroshi
AU - Nakamura, Kae
AU - Utsumi, Fumi
AU - Kajiyama, Hiroaki
AU - Okazaki, Yasumasa
AU - Toyokuni, Shinya
AU - Akiyama, Shinichi
AU - Maruyama, Shoichi
AU - Kikkawa, Fumitaka
AU - Hori, Masaru
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2018
Y1 - 2018
N2 - Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.
AB - Plasma-activated medium (PAM) is a novel chemotherapy that induces reactive oxygen species (ROS) and cell death in a wide range of cancer cell types, suggesting that PAM may be a promising therapeutic option for cancer treatment. However, dose response experiments suggest that PAM sensitivity is cell line specific. We examined the sensitivities of three glioblastoma cell lines to PAM, and found a wide variation in cell killing that was linked to differences in PAM induced ROS and apoptosis. These results indicate that the PAM sensitivity of glioblastoma cells, and potentially cancer cells more generally, is heterogeneous and likely to be dependent on the regulation of apoptosis and antioxidant pathways in target cells.
UR - https://www.scopus.com/pages/publications/85068568819
UR - https://www.scopus.com/pages/publications/85068568819#tab=citedBy
U2 - 10.1109/trpms.2017.2721973
DO - 10.1109/trpms.2017.2721973
M3 - Article
AN - SCOPUS:85068568819
SN - 2469-7311
VL - 2
SP - 99
EP - 102
JO - IEEE Transactions on Radiation and Plasma Medical Sciences
JF - IEEE Transactions on Radiation and Plasma Medical Sciences
IS - 2
ER -
