TY - JOUR
T1 - Global genetic connections of emerging G8P[8] Rotavirus A strains in Sabah, Malaysia
AU - Joseph, Julia
AU - John, Jecelyn Leaslie
AU - Amit, Lia Natasha
AU - Akari, Yuki
AU - Chin, Abraham Zefong
AU - Komoto, Satoshi
AU - Ahmed, Kamruddin
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2026.
PY - 2026/4
Y1 - 2026/4
N2 - Rotavirus A (RVA) is a major cause of acute gastroenteritis in young children, yet genomic data from Malaysia, particularly Sabah, are limited. This study reports the first whole-genome sequence analysis of two G8P[8] RVA strains (L3 and L14) detected in Sabah. Both strains displayed a DS-1-like genotype constellation and clustered closely with East Asian strains. However, VP6 and VP3 gene segments showed phylogenetic links to strains from Belgium, Cameroon and Brazil, suggesting historical global genetic exchange. These findings highlight the expanding distribution of G8P[8] and the need for continued surveillance to evaluate its epidemiological and vaccine impact.
AB - Rotavirus A (RVA) is a major cause of acute gastroenteritis in young children, yet genomic data from Malaysia, particularly Sabah, are limited. This study reports the first whole-genome sequence analysis of two G8P[8] RVA strains (L3 and L14) detected in Sabah. Both strains displayed a DS-1-like genotype constellation and clustered closely with East Asian strains. However, VP6 and VP3 gene segments showed phylogenetic links to strains from Belgium, Cameroon and Brazil, suggesting historical global genetic exchange. These findings highlight the expanding distribution of G8P[8] and the need for continued surveillance to evaluate its epidemiological and vaccine impact.
UR - https://www.scopus.com/pages/publications/105032041952
UR - https://www.scopus.com/pages/publications/105032041952#tab=citedBy
U2 - 10.1007/s00705-026-06596-3
DO - 10.1007/s00705-026-06596-3
M3 - Article
C2 - 41784634
AN - SCOPUS:105032041952
SN - 0304-8608
VL - 171
JO - Archives of Virology
JF - Archives of Virology
IS - 4
M1 - 114
ER -