Glucose transporter 2 concentrations in hyper- and hypothyroid rat livers

T. Mokuno, K. Uchimura, R. Hayashi, N. Hayakawa, M. Makino, M. Nagata, H. Kakizawa, Y. Sawai, M. Kotake, N. Oda, A. Nakai, A. Nagasaka, M. Itoh

研究成果: Article査読

37 被引用数 (Scopus)

抄録

The deterioration of glucose metabolism frequently observed in hyperthyroidism may be due in part to increased gluconeogenesis in the liver and glucose efflux through hepatocyte plasma membranes. Glucose transporter 2 (GLUT 2), a facilitative glucose transporter localized to the liver and pancreas, may play a role in this distorted glucose metabolism. We examined changes in the levels of GLUT 2 in livers from rats with L-thyroxine-induced hyperthyroidism or methimazole-induced hypothyroidism by using Western blotting to detect GLUT 2. An oral glucose tolerance test revealed an oxyhyperglycemic curve (impaired glucose tolerance) in hyperthyroid rats (n=7) and a flattened curve in hypothyroid rats (n=7), GLUT 2 levels in hepatocyte plasma membranes were significantly increased in hyperthyroid rats and were not decreased in hypothyroid rats compared with euthyroid rats. The same results were obtained with a densitometric assay. These findings suggest that changes in the liver GLUT 2 concentration may contribute to abnormal glucose metabolism in thyroid disorders.

本文言語English
ページ(範囲)285-289
ページ数5
ジャーナルJournal of Endocrinology
160
2
DOI
出版ステータスPublished - 1999

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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