Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

Yoichiro Harada, Kazuki Nakajima, Takehiro Suzuki, Tomoko Fukushige, Kiyotaka Kondo, Junichi Seino, Yuki Ohkawa, Tadashi Suzuki, Hiromasa Inoue, Takuro Kanekura, Naoshi Dohmae, Naoyuki Taniguchi, Ikuro Maruyama

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Tumor cells secrete various types of small extracellular vesicles, including exosomes and non-exosomal vesicles, each with distinct protein profiles. Through metabolic manipulation in mouse melanoma cells, Harada et al. identify N-glycosylation as a mechanism that selectively regulates non-exosomal vesicle secretion by mediating the sorting of cargo proteins into the vesicles.

本文言語English
論文番号108261
ジャーナルCell Reports
33
2
DOI
出版ステータスPublished - 13-10-2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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