Glycoproteins gM and gN of pseudorabies virus are dispensable for viral penetration and propagation in the nervous systems of adult mice

Marie Jo Masse, Alice Jöns, Johannes M. Dijkstra, Thomas C. Mettenleiter, Anne Flamand

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Glycoproteins gM and gN are conserved throughout the herpesviruses but are dispensable for viral replication in cell cultures. To assay for a function of these proteins in infection of an animal, deletion mutants of pseudorabies virus lacking gM or gN and corresponding revertants were analyzed for the ability to penetrate and propagate in the nervous systems of adult mice after intranasal inoculation. We demonstrate that neither of the two glycoproteins is required for infection of the nervous systems of mice by pseudorabies virus.

本文言語English
ページ(範囲)10503-10507
ページ数5
ジャーナルJournal of Virology
73
12
DOI
出版ステータスPublished - 12-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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