抄録
We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 277-280 |
| ページ数 | 4 |
| ジャーナル | Internal medicine (Tokyo, Japan) |
| 巻 | 31 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 02-1992 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung. / Shijubo, N.; Inoue, Y.; Hirasawa, M.; Igarashi, T.; Mori, M.; Matsuura, A.; Uede, T.; Suzuki, A.
：: Internal medicine (Tokyo, Japan), 巻 31, 番号 2, 02.1992, p. 277-280.研究成果: Article
TY - JOUR
T1 - Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung.
AU - Shijubo, N.
AU - Inoue, Y.
AU - Hirasawa, M.
AU - Igarashi, T.
AU - Mori, M.
AU - Matsuura, A.
AU - Uede, T.
AU - Suzuki, A.
PY - 1992/2
Y1 - 1992/2
N2 - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.
AB - We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.
UR - http://www.scopus.com/inward/record.url?scp=0026815371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026815371&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.31.277
DO - 10.2169/internalmedicine.31.277
M3 - Article
C2 - 1376180
AN - SCOPUS:0026815371
VL - 31
SP - 277
EP - 280
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 2
ER -