TY - JOUR
T1 - Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease
T2 - A voxel-based analysis study
AU - Kiuchi, Kuniaki
AU - Kitamura, Soichiro
AU - Taoka, Toshiaki
AU - Yasuno, Fumihiko
AU - Tanimura, Masami
AU - Matsuoka, Kiwamu
AU - Ikawa, Daisuke
AU - Toritsuka, Michihiro
AU - Hashimoto, Kazumichi
AU - Makinodan, Manabu
AU - Kosaka, Jun
AU - Morikawa, Masayuki
AU - Kichikawa, Kimihiko
AU - Kishimoto, Toshifumi
PY - 2014/8/5
Y1 - 2014/8/5
N2 - Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.
AB - Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.
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U2 - 10.1371/journal.pone.0104007
DO - 10.1371/journal.pone.0104007
M3 - Article
C2 - 25093415
AN - SCOPUS:84905484358
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 8
M1 - e104007
ER -