Green tea consumption and hematologic malignancies in Japan the ohsaki study

Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

研究成果: Article

24 引用 (Scopus)

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Several biologic studies have reported that green tea constituents have antitumor effects on hematologic malignancies. However, the effects in humans are uncertain. The authors used data from the Ohsaki National Health Insurance Cohort Study in Japan to evaluate the association between green tea consumption and the risk of hematologic malignancies. Study participants were 41,761 Japanese adults aged 40-79 years without a history of cancer at baseline who answered a food frequency questionnaire survey in 1994. During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. Hazard ratios were calculated by using the Cox proportional hazards regression model. Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). The corresponding risk estimate was 0.52 (95% confidence interval: 0.31, 0.87) for lymphoid neoplasms and 0.76 (95% confidence interval: 0.32, 1.78) for myeloid neoplasms. This inverse association was consistent across sex and body mass index strata. In conclusion, green tea consumption was associated with a lower risk of hematologic malignancies.

元の言語English
ページ(範囲)730-738
ページ数9
ジャーナルAmerican Journal of Epidemiology
170
発行部数6
DOI
出版物ステータスPublished - 01-09-2009

All Science Journal Classification (ASJC) codes

  • Epidemiology

フィンガープリント Green tea consumption and hematologic malignancies in Japan the ohsaki study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Naganuma, T., Kuriyama, S., Kakizaki, M., Sone, T., Nakaya, N., Ohmori-Matsuda, K., Hozawa, A., Nishino, Y., & Tsuji, I. (2009). Green tea consumption and hematologic malignancies in Japan the ohsaki study. American Journal of Epidemiology, 170(6), 730-738. https://doi.org/10.1093/aje/kwp187