Growth factor gene expression in kidney of murine polycystic kidney disease

Tsukasa Nakamura, Isao Ebihara, Isao Nagaoka, Yasuhiko Tomino, Shizuko Nagao, Hisahide Takahashi, Hikaru Koide

研究成果: Article

75 引用 (Scopus)

抄録

The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to that seen in the autosomal dominant form of human polycystic kidney disease. The aim of this study was to examine the mRNA expression of growth-related proteins in kidney obtained from DBA/ 2FG-pcy mice and control DBA/2 mice at 8, 16, and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA), transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF)-A and PDGF-B chains, insulin-like growth factor (IGF)-I, and basic fibroblast growth factor (bFGF) were increased with the progression of cystic lesions in the kidneys of DBA/2FG-pcy mice. At 30 wk of age, mRNA levels for PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF were increased 5.4-fold, 4.8-fold, 4.4-fold, 3.8-fold, 3.7-fold, and 4.6-fold, respectively, compared with those of control DBA/2 mice. In contrast, mRNA levels for epidermal growth factor in kidney of DBA/2FG-pcy mice decreased with age as compared with those of DBA/2 mice. These results suggest that decreased epidermal growth factor mRNA expression and increased expression of PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF mRNA may contribute to the progression of cystic lesions in DBA/2FG-pcy mice.

元の言語English
ページ(範囲)1378-1386
ページ数9
ジャーナルJournal of the American Society of Nephrology
3
発行部数7
出版物ステータスPublished - 01-01-1993

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Polycystic Kidney Diseases
Intercellular Signaling Peptides and Proteins
Proto-Oncogene Proteins c-sis
Kidney
Gene Expression
Inbred DBA Mouse
Messenger RNA
Proliferating Cell Nuclear Antigen
Transforming Growth Factors
Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Epidermal Growth Factor
Kidney Diseases
Growth
platelet-derived growth factor A
B-insulin
Proteins

All Science Journal Classification (ASJC) codes

  • Nephrology

これを引用

Nakamura, T., Ebihara, I., Nagaoka, I., Tomino, Y., Nagao, S., Takahashi, H., & Koide, H. (1993). Growth factor gene expression in kidney of murine polycystic kidney disease. Journal of the American Society of Nephrology, 3(7), 1378-1386.
Nakamura, Tsukasa ; Ebihara, Isao ; Nagaoka, Isao ; Tomino, Yasuhiko ; Nagao, Shizuko ; Takahashi, Hisahide ; Koide, Hikaru. / Growth factor gene expression in kidney of murine polycystic kidney disease. :: Journal of the American Society of Nephrology. 1993 ; 巻 3, 番号 7. pp. 1378-1386.
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abstract = "The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to that seen in the autosomal dominant form of human polycystic kidney disease. The aim of this study was to examine the mRNA expression of growth-related proteins in kidney obtained from DBA/ 2FG-pcy mice and control DBA/2 mice at 8, 16, and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA), transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF)-A and PDGF-B chains, insulin-like growth factor (IGF)-I, and basic fibroblast growth factor (bFGF) were increased with the progression of cystic lesions in the kidneys of DBA/2FG-pcy mice. At 30 wk of age, mRNA levels for PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF were increased 5.4-fold, 4.8-fold, 4.4-fold, 3.8-fold, 3.7-fold, and 4.6-fold, respectively, compared with those of control DBA/2 mice. In contrast, mRNA levels for epidermal growth factor in kidney of DBA/2FG-pcy mice decreased with age as compared with those of DBA/2 mice. These results suggest that decreased epidermal growth factor mRNA expression and increased expression of PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF mRNA may contribute to the progression of cystic lesions in DBA/2FG-pcy mice.",
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Nakamura, T, Ebihara, I, Nagaoka, I, Tomino, Y, Nagao, S, Takahashi, H & Koide, H 1993, 'Growth factor gene expression in kidney of murine polycystic kidney disease', Journal of the American Society of Nephrology, 巻. 3, 番号 7, pp. 1378-1386.

Growth factor gene expression in kidney of murine polycystic kidney disease. / Nakamura, Tsukasa; Ebihara, Isao; Nagaoka, Isao; Tomino, Yasuhiko; Nagao, Shizuko; Takahashi, Hisahide; Koide, Hikaru.

:: Journal of the American Society of Nephrology, 巻 3, 番号 7, 01.01.1993, p. 1378-1386.

研究成果: Article

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AU - Ebihara, Isao

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AU - Takahashi, Hisahide

AU - Koide, Hikaru

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N2 - The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to that seen in the autosomal dominant form of human polycystic kidney disease. The aim of this study was to examine the mRNA expression of growth-related proteins in kidney obtained from DBA/ 2FG-pcy mice and control DBA/2 mice at 8, 16, and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA), transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF)-A and PDGF-B chains, insulin-like growth factor (IGF)-I, and basic fibroblast growth factor (bFGF) were increased with the progression of cystic lesions in the kidneys of DBA/2FG-pcy mice. At 30 wk of age, mRNA levels for PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF were increased 5.4-fold, 4.8-fold, 4.4-fold, 3.8-fold, 3.7-fold, and 4.6-fold, respectively, compared with those of control DBA/2 mice. In contrast, mRNA levels for epidermal growth factor in kidney of DBA/2FG-pcy mice decreased with age as compared with those of DBA/2 mice. These results suggest that decreased epidermal growth factor mRNA expression and increased expression of PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF mRNA may contribute to the progression of cystic lesions in DBA/2FG-pcy mice.

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Nakamura T, Ebihara I, Nagaoka I, Tomino Y, Nagao S, Takahashi H その他. Growth factor gene expression in kidney of murine polycystic kidney disease. Journal of the American Society of Nephrology. 1993 1 1;3(7):1378-1386.