Growth factor gene expression in kidney of murine polycystic kidney disease

Tsukasa Nakamura, Isao Ebihara, Isao Nagaoka, Yasuhiko Tomino, Shizuko Nagao, Hisahide Takahashi, Hikaru Koide

研究成果: Article

79 引用 (Scopus)

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The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to that seen in the autosomal dominant form of human polycystic kidney disease. The aim of this study was to examine the mRNA expression of growth-related proteins in kidney obtained from DBA/ 2FG-pcy mice and control DBA/2 mice at 8, 16, and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA), transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF)-A and PDGF-B chains, insulin-like growth factor (IGF)-I, and basic fibroblast growth factor (bFGF) were increased with the progression of cystic lesions in the kidneys of DBA/2FG-pcy mice. At 30 wk of age, mRNA levels for PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF were increased 5.4-fold, 4.8-fold, 4.4-fold, 3.8-fold, 3.7-fold, and 4.6-fold, respectively, compared with those of control DBA/2 mice. In contrast, mRNA levels for epidermal growth factor in kidney of DBA/2FG-pcy mice decreased with age as compared with those of DBA/2 mice. These results suggest that decreased epidermal growth factor mRNA expression and increased expression of PCNA, TGF-β, PDGF-A and PDGF-B chains, IGF-I, and bFGF mRNA may contribute to the progression of cystic lesions in DBA/2FG-pcy mice.

元の言語English
ページ(範囲)1378-1386
ページ数9
ジャーナルJournal of the American Society of Nephrology
3
発行部数7
出版物ステータスPublished - 01-01-1993

All Science Journal Classification (ASJC) codes

  • Nephrology

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    Nakamura, T., Ebihara, I., Nagaoka, I., Tomino, Y., Nagao, S., Takahashi, H., & Koide, H. (1993). Growth factor gene expression in kidney of murine polycystic kidney disease. Journal of the American Society of Nephrology, 3(7), 1378-1386.