Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice

Eun Joo Shin, Hyeong Jhoo Jin, Toshitaka Nabeshima, Wang Kee Jhoo, Sang Kwon Myung, Yong Kwang Lim, Seok Chae Jong, Eun Jung Myung, Joo Park Seok, Jin Jang Kyung, Hyoung Chun Kim

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1-42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1-42).

本文言語English
ページ(範囲)117-120
ページ数4
ジャーナルJournal of Pharmacological Sciences
99
1
DOI
出版ステータスPublished - 2005

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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