Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice

Eun Joo Shin, Hyeong Jhoo Jin, Toshitaka Nabeshima, Wang Kee Jhoo, Sang Kwon Myung, Yong Kwang Lim, Seok Chae Jong, Eun Jung Myung, Joo Park Seok, Jin Jang Kyung, Hyoung Chun Kim

研究成果: Article

9 引用 (Scopus)


Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1-42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1-42).

ジャーナルJournal of Pharmacological Sciences
出版物ステータスPublished - 05-10-2005


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology


Shin, E. J., Jin, H. J., Nabeshima, T., Jhoo, W. K., Myung, S. K., Lim, Y. K., Jong, S. C., Myung, E. J., Seok, J. P., Kyung, J. J., & Kim, H. C. (2005). Growth hormone releaser attenuates β-amyloid (1-42)-induced memory impairment in mice. Journal of Pharmacological Sciences, 99(1), 117-120.