Growth hormone-releaser diet attenuates β-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice

Eun Joo Shin, Jong Seok Chae, Seok Joo Park, Sun Cheol Kim, Kyo Hwan Koo, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

研究成果: Article

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We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)-induced memory impairment, but the underlying mechanism remained to be characterized. We show here that the GH-releaser diet significantly attenuated Aβ(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in GH levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (IGF)-1, and IGF-1-receptor activity in mice. JB-1, an IGF-1-receptor antagonist, significantly blocked GH-releaser diet-mediated pharmacological actions. Our results suggest that the GH-releaser diet prevents Aβ(1-42)-induced cognitive deficits via stimulation of the hippocampal IGF-1 receptor.

元の言語English
ページ(範囲)139-143
ページ数5
ジャーナルJournal of Pharmacological Sciences
109
発行部数1
DOI
出版物ステータスPublished - 29-01-2009

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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