Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya, Yukihiro Akao, Kenji Matsumoto, Yoshihito Nakagawa, Ali Zulfiqar, Tetsuro Ito, Masayoshi Oyama, Hiroko Murata, Toshiyuki Tanaka, Yoshinori Nozawa, Munekazu Iinuma

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

本文言語English
ページ(範囲)1490-1492
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
29
7
DOI
出版ステータスPublished - 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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