抄録
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1490-1492 |
ページ数 | 3 |
ジャーナル | Biological and Pharmaceutical Bulletin |
巻 | 29 |
号 | 7 |
DOI | |
出版ステータス | 出版済み - 2006 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 薬理学
- 薬科学