Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya; Yukihiro Akao; Kenji Matsumoto; Yoshihito Nakagawa; Ali Zulfiqar; Tetsuro Ito; Masayoshi Oyama; Hiroko Murata; Toshiyuki Tanaka; Yoshinori Nozawa; Munekazu Iinuma

doi:10.1248/bpb.29.1490

Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

Ibrahim Iliya
, Yukihiro Akao
, Kenji Matsumoto
, Yoshihito Nakagawa
, Ali Zulfiqar
, Tetsuro Ito
, Masayoshi Oyama
, Hiroko Murata
, Toshiyuki Tanaka
, Yoshinori Nozawa
, Munekazu Iinuma

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

抄録

Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC₅₀ of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

本文言語	英語
ページ（範囲）	1490-1492
ページ数	3
ジャーナル	Biological and Pharmaceutical Bulletin
巻	29
号	7
DOI	https://doi.org/10.1248/bpb.29.1490
出版ステータス	出版済み - 2006
外部発表	はい

All Science Journal Classification (ASJC) codes

薬理学
薬科学

文献へのアクセス

10.1248/bpb.29.1490

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引用スタイル

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title = "Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells",

abstract = "Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.",

keywords = "Apoptosis, Gnemonol G, Gnetaceae, Gnetin I, Stilbenoid, Welwitschiaceae",

author = "Ibrahim Iliya and Yukihiro Akao and Kenji Matsumoto and Yoshihito Nakagawa and Ali Zulfiqar and Tetsuro Ito and Masayoshi Oyama and Hiroko Murata and Toshiyuki Tanaka and Yoshinori Nozawa and Munekazu Iinuma",

year = "2006",

doi = "10.1248/bpb.29.1490",

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T1 - Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells

AU - Iliya, Ibrahim

AU - Akao, Yukihiro

AU - Matsumoto, Kenji

AU - Nakagawa, Yoshihito

AU - Zulfiqar, Ali

AU - Ito, Tetsuro

AU - Oyama, Masayoshi

AU - Murata, Hiroko

AU - Tanaka, Toshiyuki

AU - Nozawa, Yoshinori

AU - Iinuma, Munekazu

PY - 2006

Y1 - 2006

N2 - Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

AB - Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC50 of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

KW - Apoptosis

KW - Gnemonol G

KW - Gnetaceae

KW - Gnetin I

KW - Stilbenoid

KW - Welwitschiaceae

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