Helicobacter pylori infection and gastric carcinogenesis in rodent models

Tetsuya Tsukamoto, Takeshi Toyoda, Tsutomu Mizoshita, Masae Tatematsu

研究成果: Review article査読

18 被引用数 (Scopus)

抄録

Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.

本文言語English
ページ(範囲)177-190
ページ数14
ジャーナルSeminars in Immunopathology
35
2
DOI
出版ステータスPublished - 01-03-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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