Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; A nationwide retrospective analysis in Japan

Takako Miyamura, Kazuko Kudo, Ken Tabuchi, Hiroyuki Ishida, Daisuke Tomizawa, Souichi Adachi, Hiroaki Goto, Nao Yoshida, Masami Inoue, Katsuyoshi Koh, Yoji Sasahara, Naoto Fujita, Harumi Kakuda, Maiko Noguchi, Mitsuteru Hiwatari, Yoshiko Hashii, Koji Kato, Yoshiko Atsuta, Yasuhiro Okamoto

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Objective: Pediatric acute myeloid leukemia (AML) with KMT2A rearrangement is detected in 15–20% of all pediatric AML patients and is associated with adverse outcomes even after allogeneic hematopoietic stem cell transplantation (HSCT). To investigate outcomes and prognostic factors, we investigated 90 pediatric AML patients with KMT2A rearrangement after allogeneic HSCT. Methods: We retrospectively analyzed Japanese registration data for patients who had received allogeneic HSCT between 1988 and 2011. Median age was 3 years (range, 0–15 years), and no gender difference was evident. Median observation period was 119 months. Results: The 3-year overall survival (OS) rate of KMT2A-rearranged AML was 52.1% (95% confidence interval (CI), 42.4–64%, n = 90), and the 3-year disease-free survival (DFS) rate was 46.7% (95%CI, 36.8–58.2%). The 3-year DFS of KMT2A-rearranged AML was not significantly poorer than that of other AML (P = 0.09), and no significant difference was also seen in 3-year OS rate (P = 0.21). Multivariate analysis showed disease status (complete remission) at HSCT was associated with better outcomes. A significant difference in treatment-related mortality (TRM) was apparent between HSCT from a HLA full-matched related donor and that from a haploidentical donor (P = 0.001). Discussion: HSCT is a curative option for pediatric AML with KMT2A rearrangement. Pretransplant status was the most significant prognostic indicator for relapse and survival. Enhancing supportive therapy to reduce TRM will further improve treatment outcomes of KMT2A-rearranged pediatric AML.

元の言語English
記事番号106263
ジャーナルLeukemia Research
87
DOI
出版物ステータスPublished - 12-2019

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

フィンガープリント Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; A nationwide retrospective analysis in Japan' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Miyamura, T., Kudo, K., Tabuchi, K., Ishida, H., Tomizawa, D., Adachi, S., Goto, H., Yoshida, N., Inoue, M., Koh, K., Sasahara, Y., Fujita, N., Kakuda, H., Noguchi, M., Hiwatari, M., Hashii, Y., Kato, K., Atsuta, Y., & Okamoto, Y. (2019). Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; A nationwide retrospective analysis in Japan. Leukemia Research, 87, [106263]. https://doi.org/10.1016/j.leukres.2019.106263