Hemodynamic-based mapping of neural activity in medetomidine-sedated rats using a 1.5T compact magnetic resonance imaging system: A preliminary study

Masayuki Yamada, Kazuki Takano, Yuki Kawai, Ryoichi Kato

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.

本文言語English
ページ(範囲)243-250
ページ数8
ジャーナルMagnetic Resonance in Medical Sciences
14
3
DOI
出版ステータスPublished - 11-08-2015

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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