Hemolysis test of a centrifugal pump in a pulsatile mode: The effect of pulse rate and RPM variance

Eiki Tayama, Yoshinari Niimi, Yoshiyuki Takami, Yukio Ohashi, Goro Ohtsuka, Julia A. Glueck, Juergen Mueller, Yukihiko Nosé

研究成果: Article査読

15 被引用数 (Scopus)


Centrifugal pumps are generally employed as nonpulsatile blood flow pumps; however, these pumps can produce pulsatile flow by periodically alternating the impeller rotation speed. This study investigates blood trauma due to the effect of pulse frequency and various ranges of pump speed. The hemolysis tests were conducted using the Gyro C1E3 pump. The study was divided into the following categories: Group 1 in a nonpulsatile mode; Group 2 operated at 40 bpm with 30% of speed variance; Group 3, 60 bpm with 30% of speed variance; Group 4, 40 bpm with 70% of speed variance; and Group 5, 60 bpm with 70% of speed variance. A flow rate of 3 L/min and a total pressure head of 200 mm Hg were employed in all groups to simulate a percutaneous cardiopulmonary support condition. There were no significant differences in the hemolysis levels among Groups 1, 2, and 3. However, Groups 4 and 5 exhibited a significantly higher hemolysis rate compared to the other groups. These results indicate that a high rate of speed variance increases hemolysis; however, a range of less than 30% does not affect hemolysis. The pulse rate has no significant effect on hemolysis. In conclusion, the higher speed variance increases the hemolysis level when a pulsatile mode is applied with a centrifugal pump at the given test conditions. However, a speed variance of less than 30% or a pulse rate of less than 60 bpm does not affect hemolysis.

ジャーナルArtificial Organs
出版ステータスPublished - 1997

All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学


「Hemolysis test of a centrifugal pump in a pulsatile mode: The effect of pulse rate and RPM variance」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。