Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV

Takashi Honda, Masatoshi Ishigami, Fangqiong Luo, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Akihiro Itoh, Yoshiki Hirooka, Tetsuya Ishikawa, Isao Nakano, Yoshiaki Katano, Hidemi Goto, Masatoshi Ishigami

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Obtaining a better understanding of the mechanisms associated with hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) loss in patients with hepatitis B virus (HBV) is important for treating pa-tients with chronic hepatitis B. We herein describe the case of a patient with HBV and human immunodefi-ciency virus whose chronic hepatitis was stabilized due to HBe and HBs seroconversion with the emergence of lamivudine-associated and core mutations after CD4 elevation. A full-length HBV DNA analysis indicated that HBsAg had been lost after the development of the rtS143T mutation, which corresponded to the emer-gence of the sF134L and core mutations. The details of this case shed some light on the mechanisms associ-ated with HBsAg and HBeAg clearance.

本文言語English
ページ(範囲)585-590
ページ数6
ジャーナルInternal Medicine
54
6
DOI
出版ステータスPublished - 2015

All Science Journal Classification (ASJC) codes

  • 内科学

フィンガープリント

「Hepatitis B e antigen and hepatitis B surface antigen seroclearance with the emergence of lamivudine-associated and core mutations following CD4 elevation in a patient with hepatitis B and HIV」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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