Hepatitis C virus utilizes VLDLR as a novel entry pathway

Saneyuki Ujino, Hironori Nishitsuji, Takayuki Hishiki, Kazuo Sugiyama, Hiroshi Takaku, Kunitada Shimotohno

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Various host factors are involved in the cellular entry of hepatitis C virus (HCV). In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Culturing Huh7.5 cells under hypoxic conditions significantly increased HCV entry as a result of the expression of VLDLR, which was not expressed under normoxic conditions in this cell line. Ectopic VLDLR expression conferred susceptibility to HCV entry of CD81-deficient Huh7.5 cells. Additionally, VLDLR-mediated HCV entry was not affected by the knockdown of cellular factors known to act as HCV receptors or HCV entry factors. Because VLDLR is expressed in primary human hepatocytes, our results suggest that VLDLR functions in vivo as an HCV receptor independent of canonical CD81-mediated HCV entry.

本文言語English
ページ(範囲)188-193
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
113
1
DOI
出版ステータスPublished - 05-01-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

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