TY - JOUR
T1 - Heritability of brain volume on MRI in middle to advanced age
T2 - A twin study of Japanese adults
AU - Lukies, Matthew W.
AU - Watanabe, Yoshiyuki
AU - Tanaka, Hisashi
AU - Takahashi, Hiroto
AU - Ogata, Soshiro
AU - Omura, Kayoko
AU - Yorifuji, Shiro
AU - Tomiyama, Noriyuki
N1 - Publisher Copyright:
© 2017 Lukies et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/4
Y1 - 2017/4
N2 - Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population.
AB - Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population.
UR - https://www.scopus.com/pages/publications/85018501393
UR - https://www.scopus.com/pages/publications/85018501393#tab=citedBy
U2 - 10.1371/journal.pone.0175800
DO - 10.1371/journal.pone.0175800
M3 - Article
C2 - 28426696
AN - SCOPUS:85018501393
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 4
M1 - e0175800
ER -