Herpes simplex virus encodes a virion-associated protein which promotes long cellular processes in over-expressing cells

H. Takakuwa, F. Goshima, T. Koshizuka, T. Murata, T. Daikoku, Y. Nishiyama

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Background: Herpes simplex virus (HSV) possesses a number of accessory genes which are dispensable for replication in cell culture. A previous study showed that the UL21 gene product of HSV type 1 is a virion component that is not necessary for viral replication. The function of the gene product remains unknown. Results: We found that the HSV-1 UL21 gene product, a capsid-associated tegument protein with an apparent molecular mass of 62 kDa, promotes the outgrowth of long cellular processes when it is over-expressed in non-neural cells. The UL21 protein co-localizes and physically associates with microtubules in the long processes. Analysis using mutant proteins implicates a proline-rich region in promotion of the processes. Conclusions: The results suggest that the UL21 protein, like tau and other MAPs, promotes the process by directly or indirectly interacting with microtubules and facilitates the intracellular transport of the virus.

本文言語English
ページ(範囲)955-966
ページ数12
ジャーナルGenes to Cells
6
11
DOI
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 細胞生物学

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