抄録
This chapter deals with the four most recently discovered herpesviruses: the human herpesviruses HHV-6A, HHV-6B, HHV-7, and HHV-8 (also called Kaposi sarcoma-associated herpesvirus). Today know that HHV-6B is the virus that causes the majority of the disease associated with HHV-6. Other clinical associations such as bone marrow suppression, pneumonia, and skin rash mimicking acute graft-versus-host disease (GVHD) have been proposed. The importance of HHV-6A, HHV-7, and HHV-8 is less in stem-cell transplant recipients, although cases with likely pathology due to these viruses have been documented. HHV-6B is an important pathogen in HCT patients primarily through its CNS effects.The risk is highest in patients after cord blood (CB) transplantation and this is a group where it would be logical to implement preventive measures. CMX001 is a drug in clinical development that might be a future alternative. Adoptive transfer of HHV-6-specific T cells might also be a possible management strategy.
本文言語 | English |
---|---|
ホスト出版物のタイトル | Thomas' Hematopoietic Cell Transplantation |
ホスト出版物のサブタイトル | Fifth Edition |
出版社 | Wiley-Blackwell |
ページ | 1122-1131 |
ページ数 | 10 |
巻 | 2-2 |
ISBN(電子版) | 9781118416426 |
ISBN(印刷版) | 9781118416006 |
DOI | |
出版ステータス | Published - 01-01-2016 |
All Science Journal Classification (ASJC) codes
- Medicine(all)