High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns

Mohamed Hamed Hussein, Ghada A. Daoud, Hiroki Kakita, Shin Kato, Tatenobu Goto, Michi Kamei, Kenji Goto, Masanori Nobata, Yasuhiko Ozaki, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Satoshi Suzuki, Hisanori Sobajima, Fujio Hara, Takashi Hashimoto, Hajime Togari

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.

本文言語English
ページ(範囲)422-429
ページ数8
ジャーナルFree Radical Research
44
4
DOI
出版ステータスPublished - 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry

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