High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

Hai Quyen Tran, Yoon Hee Chung, Eun Joo Shin, Won Ki Kim, Jae Chul Lee, Ji Hoon Jeong, Myung Bok Wie, Choon Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

研究成果: Article

2 引用 (Scopus)

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Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed.

元の言語English
ページ(範囲)166-170
ページ数5
ジャーナルJournal of Pharmacological Sciences
132
発行部数2
DOI
出版物ステータスPublished - 01-10-2016

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Tran, H. Q., Chung, Y. H., Shin, E. J., Kim, W. K., Lee, J. C., Jeong, J. H., Wie, M. B., Jang, C. G., Yamada, K., Nabeshima, T., & Kim, H. C. (2016). High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. Journal of Pharmacological Sciences, 132(2), 166-170. https://doi.org/10.1016/j.jphs.2016.10.001